Healthy Ageing: Chronological Age Versus Biological Age
Biological age is a measure of your age based on biomarkers which is the function of the vital organs of the body at the cellular and molecular level. Biological age is determined by hormones, myelination in the brain and other lifestyle factors such as diet, exercise, stress, sleep, etc. More recently, the yale school of medicine publication has emerged as perhaps the Epigenetic Testing most comprehensive and well-researched approach to biological aging. The study was based on data from 10,000 participants in a study conducted from 1988 to 1994 in which they tried to identify key metrics that could more accurately predict life expectancy. Based on those findings, they created a subsequent study of 11,000 people, which was conducted from 1999 to 2010.
I recently had problems with blurred vision and tingling and pain in the bottom of one foot. I knew my glucose was high, so I started testing and brought my glucose into the normal range. There are a few key areas that contribute to rapid aging and the increased risk of chronic disease as you age.
As pioneers in age management, Cenegenics has remained at the forefront of closely studying the biological factors of aging and has helped our patients reduce this critical measure for 23 years. In fact, we pioneered the medical specialty of Age Management, and one of our doctors even wrote the textbook that was used to teach other doctors the main theories behind optimal health through aging. That’s why we support yale school of medicine research in their findings and believe that biological aging is one of the most important factors for people to understand and address.
Nicotinamide adenine dinucleotide precursors, such as nicotinamide riboside and nicotinamide mononucleotide, are another group of sirtuin activators that improve vascular aging in mice. Preliminary human studies suggested its potential use to reduce arterial stiffness and blood pressure, and a clinical trial was launched in 2019. It is no coincidence that the same factors are the pillars of the Cenegenics programme. We take a very scientific approach to working on creating a body that is perfectly tuned to the cellular level to function ideally, reducing your biological age and rebalancing your body to where it was in its 20s or 30s. We tailor recommendations to your precise needs so you feel your best, both now and at all ages.
However, moderate alcohol consumption correlates with a lower incidence of DKA and has some cardiometabolic benefits. Other factors that influence aging and longevity include air quality, sleep duration and quality, psychological factors, and socioeconomic status (67-71). Aging is the main risk factor for vascular disease and the resulting cardiovascular and cerebrovascular events, the leading causes of death worldwide.
Physical inactivity is a major risk factor for mortality, and even small amounts of exercise reduce CVD and all-cause mortality. Another important modulator of vascular function and CVD risk is diet, with healthy aging linked to unprocessed, plant-based diets with moderate consumption of lean meats and fish, characteristic of Mediterranean and dietary diets to stop hypertension. The main components of Western diets that promote atherosclerosis and hypertension are refined sugars, processed meats, hydrogenated vegetable oils, and large amounts of salt. Aside from the types of foods consumed, the amount of food ingested plays a crucial role in aging, as overeating increases the risk of obesity, CVD, and death. In particular, the exceptional longevity of the Japanese on the island of Okinawa, a blue zone, was partly attributed to the slight and steady reduction in calorie intake. Smoking, drug and alcohol abuse are unequivocally linked to accelerated vascular aging and shorter life expectancy.
One of the main types of epigenetic modifications that occur as people age is DNA methylation, a process in which functional groups are added to DNA over time. The amount of DNA methylation present in your DNA is directly correlated with the age of your cells. The more methyl groups present in your DNA, the older your cells will behave, making measuring DNA methylation the most reliable way to measure biological age.